Representative Tom Price, President-elect Donald Trump's nominee to lead the Department of Health and Human Services, will appear for the first time before U.S. senators Wednesday amid growing ethics concerns and uncertainty among Republicans about how they will repeal and replace Obamacare.

In the hearing on his nomination, Price will likely face questions about his stock trades in health companies while handling health-related legislation; plans to repeal Obamacare; and Trump's recent comments about requiring pharmaceutical companies to bid for government business. Price, an orthopedic surgeon from Georgia, has opposed allowing Medicare, the U.S. health program for the elderly, to negotiate drug prices directly with manufacturers.  

Price will be a key player in the GOP's efforts to dismantle the Affordable Care Act, the outgoing president's signature law known as Obamacare. Trump said last week he wants to propose a plan to end and replace Obamacare as soon as Price is confirmed, although he gave no details about what the replacement would look like.