Wanted: Chief executive for health-care startup. Must be able to reinvent an industry, reduce spiraling costs and improve care for one million people — and possibly the entire nation.

Reply to: Three billionaires.

Amazon.com Inc., Berkshire Hathaway Inc. and JPMorgan Chase & Co. are teaming up to try to solve the seemingly insurmountable mess that's the U.S. health-care system. Their venture raises a crucial question of who could run such an enterprise.

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