Forget all the other drivers of health care costs. There's one that's often overlooked: Consumers who don't follow doctor's orders — at least in terms of prescription drugs. And the lack of adherence is costing the country billions.

MediSafe — a company behind a free mobile app that lets users track their medication usage and guidelines online — collected data from 1.7 million individual medication consumption cases across the country.

Their analysis found that 10 cities lead the way in driving up health care costs each year from prescription non-adherence — including costs from avoidable hospitalizations, nursing home admissions and premature deaths.

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