April 10 (Bloomberg) — Kathleen Sebelius, the U.S. health secretary who steered the troubled rollout of President Barack Obama's signature health care law, will resign just as the program topped its first-year enrollment goal.

The president will announce Sebelius's resignation tomorrow and name Sylvia Mathews Burwell, 48, director of the Office of Management and Budget, as the health department's next secretary, the White House said.

A former Democratic governor of Kansas, Sebelius, 65, was an early backer of Obama's campaign for president. She spent five years running the Health and Human Services Department, presiding over the largest change to government health programs since Medicare and Medicaid began almost 50 years ago.

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