(Bloomberg) — After topping initial enrollment projections for the 2010 Patient Protection and Affordable Care Act (PPACA), Kathleen Sebelius, the U.S. health secretary, leaves her successor, Sylvia Mathews Burwell, an agency with numerous challenges to ultimately make the law work.

PPACA faces continued battles in court and in Congress, where Republicans haven't dropped efforts to repeal or gut the measure. The Health and Human Services Department also is faced with helping the $3.1 trillion U.S. health-care industry continue to adapt to the overhaul and its millions of newly insured beneficiaries.

President Barack Obama will announce the resignation of Sebelius and the nomination of Burwell, currently the director of the Office of Management and Budget, at the White House this morning, officials said. Both women will attend.

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