(Bloomberg) -- A Democratic senator is holding up PresidentBarack Obama’s nominee for head of the U.S. Food and DrugAdministration, calling for changes in how the agency approvesprescription painkillers that havebeen at the center of a deadly epidemic of drug abuse.

Senator Edward Markey of Massachusetts put a hold on Obama’snomination of Robert Califf, a renowned cardiologist from DukeUniversity, to serve as commissioner of the FDA, according to astatement from the senator’s office Monday.

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