The U.S. Senate overwhelmingly approved President Obama's nominee to head the Food and Drug Administration Wednesday, despite an effort by a small group of senators to block the confirmation as a way to demonstrate their objection to the agency's record on prescription painkillers. 

The Senate voted 89-4 to confirm Dr. Robert Califf to head the agency for the remainder of Obama's term. The four no votes came from three Democrats — Joe Manchin of West Virginia, Edward Markey of Massachusetts and Richard Blumenthal of Connecticut — along with New Hampshire Republican Kelly Ayotte. 

"FDA stands for Food and Drug Administration, but over the last 20 years it really stands for 'fostering drug addiction,' " Markey said on the Senate floor, according to the New York Times. "We have to have an honest discussion about the role that agency is playing." 

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