The pharmaceutical industry’s powerfulWashington trade association fell in size by almost two dozencompanies after revising membership rules amid the debate overU.S. drug prices.

Pharmaceutical Research and Manufacturers of America, or PhRMA,will require that members spend at least $200 million a year onresearch and development and that their R&D spending is atleast 10 percent of global sales.

The changes, reported by Bloomberg Sunday, follow a three-monthreview that has already seen several member companies leave thelobbying group.

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