COLUMBUS, Ohio — Lawmakers in the nation's capital have yet to grapple with rising drug costs, but Ohio voters are being asked — in a single ballot-box question next week — to figure out how best to lower the tab the state pays for prescriptions.

The Drug Price Relief Act, better known as Ohio Issue 2, has been promoted and pilloried in a dizzying crush of robocalls, TV and radio ads, and direct mailings.

Opponents say it is impossible to implement, could limit patients' access to medicines and would not necessarily save money. Proponents are selling the initiative as a rebellion that could save millions of dollars in an era of health care anxiety.

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