Drug costs Major PBMs are increasingly denying coverage of some drugs, negotiating discounts on others or requiring high co-pays for expensive treatments. (Photo: Shutterstock)

It’s It’s a tough time to be a middleman in the U.S. pharmacy business.

Jeff Bezos is teaming up with two fellow billionaires in what could be a prelude to bigger plans to undercut the dominance of intermediaries in the country’s complex health-care system. Pharma companies are trying to shift the blame onto them for soaring drug prices. And costly new medicines are getting approved at a record pace pace by regulators in Washington.

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