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Opioid pills Opioid pills. Photo: Kimberly Boyles/Shutterstock.com

Insys Therapeutics has agreed to pay $225 million to resolve civil and criminal actions brought by the U.S. Department of Justice over alleged kickbacks and marketing of its opioid painkiller.

Under the deal, announced Wednesday, Insys agreed to pay $195 million to settle allegations in five separate whistleblower lawsuits that it violated the False Claims Act. Its operating subsidiary also will plead guilty to five counts of mail fraud and pay a $2 million fine and $28 million in forfeiture. Both parts of the settlement center on Subsys, a fentanyl spray that Insys manufactured and that the U.S. Food and Drug Administration approved in 2012 for the treatment of chronic pain in cancer patients.

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