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This Tuesday, May 8, 2007, file photo shows the Purdue Pharma logo at its offices in Stamford, Conn. The company is facing some 2,000 lawsuits in the United States over its role in unleashing an addiction crisis that has claimed 400,000 lives. More than a dozen defendants face numerous claims at next month’s trial, which will take place in Cleveland.  (AP Photo: Douglas Healey, File)

Manufacturers of prescription opiates lost a key ruling Monday involving public nuisance claims as pressure against them mounts ahead of a closely watched trial next month.

U.S. District Judge Dan Polster of the Northern District of Ohio, who will oversee the Oct. 21 jury trial, refused to toss claims that the opioid manufacturers, which include Purdue Pharma and Johnson & Johnson, created a public nuisance. The ruling applies to two Ohio counties serving as plaintiffs in the first federal trial over the opioid crisis.

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