Doctor and business man holding up medication concepts The largest PBMs have the advantage of size and negotiating power, and access to an extensive portfolio of specialty, brand, and generic medications. (Photo: Shutterstock)

Two new pharmacy benefit managers (PBMs) are looking to disrupt the industry: Mark Cuban's Cost Plus Drug Company and the Purchaser Business Group on Health (PBGH), a nonprofit coalition. Both companies are looking to promote drug pricing transparency, which larger PBMs like CVS and United HealthCare have been reluctant to do. Converse views and legislative efforts around drug pricing have continued to elevate over the past few decades.

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