Being the middleman standing between drugmakers and insurance companies is getting to be more uncomfortable.

Health insurance giant Anthem Inc. moved to sever ties with pharmacy-benefits manager Express Scripts Holding Co. on Wednesday, opting instead to build its own such business in collaboration with CVS Health Corp. as it looks to contain its spiraling drug costs.

The pharmacy-benefits management business has been under widening scrutiny. Lawmakers, consumers and insurers, among others, have complained that pharmacy-benefits managers, or PBMs, use opaque deals and rebates to pad their profits. Several states have tried to enhance transparency around the business despite an aggressive industry pushback.

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